Description: This presentation will review the available literature on the use of intravenous thrombolysis beyond the conventional 4.5-hour treatment window, both in conjunction with mechanical thrombectomy and as a standalone therapy. It will also examine current guideline recommendations and provide a comprehensive overview of acute ischemic stroke, including background, management strategies, and treatment considerations.

Microsoft Teams Meeting link to join the live session: Register Here

Speaker: Cristina Pecoraro, PharmD, PGY2 Critical Care Pharmacy Resident - Aurora Health Care Metro, Inc)  

Objectives: ​​ 

  • Recall the pharmacology and pharmacokinetics of thrombolytic agents used in acute ischemic stroke
  • Outline current guidelines and criteria for thrombolytic administration, including the traditional 4.5-hour window
  • State recent clinical trial data supporting thrombolytic use beyond the standard treatment window
  • Select an evidence-based approach to thrombolytic therapy timing for patients presenting outside the traditional window

Target Audience:​ Advocate Pharmacists, Physicians, Nurses, and other interested healthcare professionals

Disclosure:​ The planner(s) and speaker(s) have indicated that there are no relevant financial relationships with any ineligible companies to disclose. 

Activity Flyer: File Single Activity Flyer - CPecoraro.docxPDF icon CPecoraro Thrombolytics After the Window Expanding the Stroke Treatment Timeline Audience Copy Updated.pdf

Session date: 
11/18/2025 - 12:00pm to 1:00pm CST
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  • 1.00 AMA PRA Category 1 Credit™
    Aurora Health Care is accredited by the Wisconsin Medical Society to provide continuing medical education for physicians. Aurora Health Care designates this activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
  • 1.00 Attendance
    Attendance Credit
    • 1.00 Approved AMA PRA Category 1 Credit™
  • 1.00 Continuing Nursing Education (CE)
    Aurora Health Care is an approved provider of continuing nursing education by the Wisconsin Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation. 1.00 contact hours have been awarded to this activity by the Wisconsin Nursing Association. To receive contact hours, participants must attend the entire activity.
    • 1.00 APRN Pharmacotherapeutic Contact Hours
  • 1.00 Continuing Pharmacy Education (CPE)
    Aurora Health Care Department of Pharmacy Services is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
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