Description: This presentation will provide an evidence‑based overview of treatment sequencing strategies for hormone receptor-positive, HER2‑negative metastatic breast cancer. Will review subsequent line therapy options as well as targeted therapies, factors influencing therapy selection, and treatment sequencing principles to support optimal therapeutic decision‑making across lines of treatment.

Microsoft Teams Webinar link to register for the live session: Register Here

Speaker: Julianna Kuecker, PharmD – PGY2 Oncology Pharmacy Resident – Aurora Health Care Metro, Inc

Objectives: ​​ 

  1. Evaluate evidence‑based sequencing strategies following progression for HR+/HER2‑ metastatic breast cancer, including subsequent treatment line options and targeted therapies.
  2. Interpret key biomarkers and explain how they inform individualized therapy selection and sequencing decisions.
  3. Identify mechanisms of resistance to targeted therapies and assess strategies to overcome or manage resistance in subsequent treatment lines.
  4. Describe practical approaches to optimizing patient care, including toxicity management, drug–drug interaction mitigation, and supportive care considerations when sequencing targeted agents.

Target Audience:​ Advocate Pharmacists, Physicians, Nurses, and other interested healthcare professionals

Disclosure:​ The planner Alex Wolff was an advisory board member for Bristol Myers Squibb. The relationship ended 9/25/25. She was also an advisory board member for Syndax Pharmaceuticals. The relationship ended 4/9/25. She was also an advisory board member for Incyte Pharmaceuticals.  The relationship ended 3/25/26.  The other planner(s) and speaker(s) have indicated that there are no relevant financial relationships with any ineligible companies to disclose. All of the relevant financial relationships listed for Alex Wolff have been mitigated. 

Materials:  PDF icon Single Activity Flyer-Live Kuecker 52126.pdf

Pharmacist UAN: JA0006327-0000-26-001-L01-P

Session date: 
05/21/2026 - 12:00pm to 1:00pm CDT
Location: 
Aurora St. Lukes Medical Center Family Practice LL and Virtual Via Teams
United States
See map: Google Maps
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  • 1.00 AMA PRA Category 1 Credit™
    Aurora Health Care is accredited by the Wisconsin Medical Society to provide continuing medical education for physicians. Aurora Health Care designates this activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
  • 1.00 Attendance
    Attendance Credit
    • 1.00 Approved AMA PRA Category 1 Credit™
  • 1.00 Continuing Nursing Education (CE)
    Aurora Health Care is an approved provider of continuing nursing education by the Wisconsin Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation. 1.00 contact hours have been awarded to this activity by the Wisconsin Nursing Association. To receive contact hours, participants must attend the entire activity.
    • 1.00 APRN Pharmacotherapeutic Contact Hours
  • 1.00 Continuing Pharmacy Education (CPE)
    Aurora Health Care Department of Pharmacy Services is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
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