Description: Direct oral anticoagulants (DOACs) present unique challenges and opportunities when used in patients at the extremes of body weight, where pharmacokinetic and pharmacodynamic changes can meaningfully alter drug exposure. Emerging evidence suggests that certain DOACs maintain efficacy and safety in both underweight and obese populations, though the application of this evidence is up for debate. This presentation aims to synthesize available literature, including published guidelines and real‑world evidence, to clarify when DOAC therapy may be appropriate in these patients.

Microsoft Teams Webinar link to register for the live session: Register Here

Speaker: Avery North, PharmD, PGY1 Pharmacy Resident in the Ambulatory Care Setting - Atrium Health Cabarrus

Objectives: ​​ 

  1. Understand the proposed pharmacokinetic and pharmacodynamic changes in anticoagulation therapy in patients of weight extremes
  2. Identify current guideline recommendations for anticoagulation in patients who are underweight or obese
  3. Summarize available literature to assess the efficacy and safety of direct oral anticoagulant (DOACs) in underweight and obese patient populations
  4. Recognize appropriate anticoagulant therapy in patients of weight extremes

Target Audience:​ Advocate Pharmacists, Physicians, Nurses, and other interested healthcare professionals

Disclosure:​ The planner(s) and speaker(s) have indicated that there are no relevant financial relationships with any ineligible companies to disclose. 

Materials: PDF icon Single Activity Flyer-Live-A North.pdf

Pharmacist UAN: JA0006327-0000-26-001-L01-P

Session date: 
03/24/2026 - 12:00pm to 1:00pm CDT
Location: 
Virtual via Teams Webinar
United States
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  • 1.00 AMA PRA Category 1 Credit™
    Aurora Health Care is accredited by the Wisconsin Medical Society to provide continuing medical education for physicians. Aurora Health Care designates this activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
  • 1.00 Attendance
    Attendance Credit
    • 1.00 Approved AMA PRA Category 1 Credit™
  • 1.00 Continuing Nursing Education (CE)
    Aurora Health Care is an approved provider of continuing nursing education by the Wisconsin Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation. 1.00 contact hours have been awarded to this activity by the Wisconsin Nursing Association. To receive contact hours, participants must attend the entire activity.
    • 1.00 APRN Pharmacotherapeutic Contact Hours
  • 1.00 Continuing Pharmacy Education (CPE)
    Aurora Health Care Department of Pharmacy Services is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
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